P02.62. DHEA augmentation strategy for treatment of fatigue and depression: a case presentation
نویسندگان
چکیده
Purpose Dehydroepiandrosterone (DHEA) and its sulfated derivative DHEA-S are endogenous hormones secreted by the adrenal cortex in response to ACTH and stress. Levels of DHEA and DHEA-S are decreased with advancing age and depression. Trials of DHEA for mid-life depression have shown promising yet inconclusive results, due in part to small sample sizes and lack of placebo comparators. An additional concern, with the risk of breast cancer in this age group, is the high doses of DHEA supplementation used. We present a case in which low-dose topical DHEA and other hormonal agents were used as an adjunct to conventional antidepressant therapy to target symptoms of depression and fatigue in a peri-menopausal woman.
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